However, because of the high frequency of thyroid disease in women with menstrual disorders, the assessment of thyroid function, together with the exclusion of other diseases, including hyperprolactinemia, acromegaly, genetic defects in insulin action, primary hypothalamic amenorrhea, primary ovarian failure, and syndrome of severe insulin resistance was recommended in other articles (1, 3–6, 13). Here, INS is linked to acromegaly.