TSHR and polycystic ovary syndrome: Interestingly, the authors also observed an increased TSH receptor expression and cyclic adenosine monophosphate concentration in granulosa cells of patients with PCOS, suggesting a possible detrimental effect of TSH on the PCOS ovary mediated via TSH receptor/cyclic adenosine monophosphate (184) with a potential reduction of oocyte competence in women with PCOS (165).