A systematic review with a meta-analysis (148) of 12 studies, including a total of 2341 women with PCOS (577 with SCH versus 2077 euthyroid control groups), concluded that SCH in women with PCOS does not influence the clinical profile (systolic and diastolic blood pressure, waist circumference, waist/hip ratio, and BMI), hormonal profile (prolactin, FSH, LH, LH/FSH ratio), and metabolic profile (serum SHBG and LDL cholesterol levels, and insulin resistance indexes) profile of women with PCOS (148). This evidence concerns the gene PLOD1 and Insulin resistance.