In addition to harming the previously described direct central effects of dopamine in the mesolimbic area, blocking D2 receptors in the tuberoinfundibular pathway also increases prolactin levels, thus leading to an increase of opioid and GABA levels as well as a reduction of testosterone levels resulting in hypogonadotropic hypogonadism. Here, PRL is linked to hypogonadotropic hypogonadism.