INS and obesity due to melanocortin 4 receptor deficiency: In addition, subgroup analyses by BMI percentile indicated a significant reduction in fasting insulin for adolescents with overweight [SMD=-0.62 (95% CI -0.97 to -0.26), p=0.001, 16 interventions], and with obesity [SMD=-0.87 (95% CI -1.2 to -0.55), p=0.001, 24 interventions], compared with a control group.