POR and hyperinsulinemic hypoglycemia, familial, 4: Cytochrome P450 oxidoreductase deficiency (PORD) is a rare type of congenital adrenal hyperplasia (CAH) inherited in an autosomal recessive manner caused by cytochrome P450 oxidoreductase (POR) mutations, which results in multiple hormonal imbalances with phenotypic diversity (1–5).