The elevated circulating sLRP1 levels in T2DM patients found here are in line with the documented increased LRP1 levels in the epicardial fat of T2DM patients (16) and in the myocardium of diabetic rats (13), and also with the close association between blood sLRP1 levels and the extension of epicardial fat in patients with type 1 diabetes and in the general population (17, 18). This evidence concerns the gene LRP1 and type 2 diabetes mellitus.