To analyze the evolution of circulating levels of sLRP1 and ANP, and of the sLRP1/ANP ratio according to the glycemic control, the changes in these variables from T2DM onset (Pre) to T2DM-1-year (Post) were analyzed in strict glycemic control (HbA1c ≤ 6.5%) versus less strict glycemic control (HbA1c > 6.5%) patients (Figure 1). This evidence concerns the gene NPPA and type 2 diabetes mellitus.