Interestingly, we and other investigators have expanded the principles behind PMCA to amplify and detect other prion-like misfolded proteins (e.g., amyloid-beta, tau, alpha-synuclein) implicated in highly prevalent neurodegenerative diseases, including Alzheimer’s, Parkinson’s disease and dementia with Lewy bodies (Salvadores et al., 2014; Fairfoul et al., 2016; Shahnawaz et al., 2017; Metrick et al., 2020; Saijo et al., 2020; Siderowf et al., 2023). Here, SNCA is linked to neurodegenerative disease.