However, in a doxycycline-regulated Myc transgenic model of HCC, glutamine transporter SLC1A5 is highly expressed, and GLS1/GLS2 is downregulated in both transcripts and protein, which indicates increased extracellular glutamine uptake to anabolic pathway other than fuel source for the TCA cycle (Dolezal et al., 2017). The gene discussed is GLS2; the disease is hepatocellular carcinoma.