GLS and neoplasm: bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide (BPTES) and CB-839, GLS inhibitors are confirmed to have anti-tumor effective; especially CD839 has been proved to possess the ability of antiproliferative activity in both solid tumors like pancreatic cancer and breast cancer (Gross et al., 2014; Biancur et al., 2017).