CD44 and hepatocellular carcinoma: Cholesterol can not only induce ectopic fatty acids accumulation, reshape an immunosuppressive microenvironment, activate hepatic stellate cells, and influence membrane fluidity or protein function, to further promote tumorigenesis in HCC but also activate NK cell proliferation or recruitment, and promote CD44 translocation into lipid rafts, so that prohibit HCC (Zhou and Sun, 2021).