TPO and autoimmune thrombocytopenic purpura: Although several studies have proposed that antiviral drugs increase platelet counts in patients with HBV or HCV infection, these drugs are often contraindicated in those with severe thrombocytopenia (<50 × 109/L).40Currently, treatments recommended for viral hepatitis associated with ITP include glucocorticoids, rhTPO, TPO-RAs, and splenectomy.