ZMPSTE24 and pancreatic insulinoma: Overexpression of Ste24 suppressed 6xIAPP toxicity, whereas deletion of Ste24 exacerbated it; expression of ZMPSte24 suppressed 6xIAPP toxicity in a STE24Δ mutant, illustrating a conserved protease function in clog destruction; expression of Ste24 protected rat insulinoma cells against toxicity mediated by 6xIAPP expression (Ast et al., 2016; Kayatekin et al., 2018).