By using lipopolysaccharide (LPS) to establish S-AKI models in animals and cells, and inhibiting Drp1 activity with mdivi-1, it was found that it is possible to reduce the activation of the NLRP3 inflammasome-mediated pyroptosis pathway, thereby improve S-AKI in animals and cells (Liu et al., 2020). Here, DNM1L is linked to acute kidney injury.