The increased expression of JAK2 in podocytes and other glomerular and tubulointerstitial cells in Akita diabetic podocyte JAK2 mice further leads to DKD-related pathological changes, such as albuminuria, mesangial dilatation, glomerular sclerosis, and renal fibrosis (Zhang et al., 2017). The gene discussed is JAK2; the disease is renal fibrosis.