The increased expression of JAK2 in podocytes and other glomerular and tubulointerstitial cells in Akita diabetic podocyte JAK2 mice further leads to DKD-related pathological changes, such as albuminuria, mesangial dilatation, glomerular sclerosis, and renal fibrosis (Zhang et al., 2017). This evidence concerns the gene JAK2 and Glomerular sclerosis.