Another intriguing finding is that JAK2 expression was significantly increased in the glomeruli of patients with early DKD, and JAK2 expression was more significantly upregulated in the tubulointerstitial region of patients with progressive DKD, which corresponds to the natural progression of pathological changes in glomerular damage followed by tubulointerstitial pathological changes in DKD (Berthier et al., 2009). Here, JAK2 is linked to diabetic kidney disease.