The recent publication of further studies evaluating adjunctive treatment with IgM-enriched immunoglobulin in pediatric and neonatal sepsis, have prompted this systematic review, the aim of which is to provide an updated analysis and review of studies that assess the effectiveness of IgM-enriched immunoglobulin as adjunctive therapy in pediatric and neonatal sepsis. The gene discussed is CD40LG; the disease is Neonatal sepsis.