SLC25A15 and hepatocellular carcinoma: SLC25A15 is a gene that controls the urea cycle, and we selected several other genes related to the urea cycle to demonstrate IHGA's functionality for comparing the expression levels of multiple genes, as shown in Fig. 3E. SLC25A15 and other urea cycle–related genes show a low-expression trend in most HCC datasets, which is consistent with literature reports that the urea cycle is disrupted in HCC [20].