HNF4A and hepatocellular carcinoma: For example, we used SLC25A15 and its upstream regulatory gene HNF4A to group patients, and the results showed that patients with low expression of both SLC25A15 and HNF4A had the worst overall and disease-free survival (Fig. 6C), suggesting the important role of the HNF4A/SLC25A15 pathway in HCC.