We checked RFX6, FOXF1, PDX1, IHH, and SHH, and we identified (≥1 loss‐of‐function or missense variants, AF ≤0.005) two rare heterozygous missense variants in the PDX1 gene (p.Ala104Asp) and the FOXF1 gene (p.Met257Ile; Table 4). Here, PDX1 is linked to atrial fibrillation.