Furthermore, overexpression of FBN1 remarkably restored the cell proliferation (Figure 5C) and inhibited cell apoptosis (Figure 5D) as compared to control, suggesting that MFAP2 mediated TGF‐β/Smad3 signalling pathway and fibrotic markers during liver fibrosis by upregulating the expression of FBN1. This evidence concerns the gene MFAP2 and Hepatic fibrosis.