CREBBP and urinary bladder cancer: In the feline UC samples, it was interesting to note deletion of the transcriptional co-activators and chromatin remodelling genes, CREBBP and NCOR1, as 57/97 (59%) of human UC patients harbor nonsynonymous mutations in chromatin remodelling genes (including CREBBP and NCOR1) [56], which suggests that aberration of chromatin regulation might be a hallmark of urinary bladder cancer [56].