The increment of serological nesfatin-1 may be caused by continuously overexpressed NUCB-2 in NPC tissue; following lysis of the NPC cell, NUCB-2 is released from the cell and digested by prohormone convertase (PC) and caspase, then nesfatin-1, the main fragment of NUCB-2, is secreted into the blood, which consequently lead to its elevation in serum. This evidence concerns the gene NUCB2 and nasopharyngeal carcinoma.