Despite the limitation of this study that, as it is a cross-sectional survey, the effects of NUCB-2 on the progression of NPC have not been explored adequately, to the best of our knowledge, this is the first study involving a large number of clinical samples to verify the regulation of NUCB2 on the occurrence and development of nasopharyngeal carcinoma. This evidence concerns the gene NUCB2 and nasopharyngeal carcinoma.