NUCB2 and nasopharyngeal carcinoma: Nesfatin-1 test combined with VCA-IgA and Rta-IgG exhibits impressive sensitivity (93.6%) and specificity (94.5%) in the diagnosis of primary NPC, together with high positive and negative predictive values of 89.8% and 96.6%, while the accuracy reached 94.2% and yoden index was 0.881 (Fig. 5).