Of them, nucleobindin-2 (NUCB-2) was up-regulated with a 6-10B/NP69 ratio of 2.19 and a 5-8 F/NP69 ratio of 2.26, and nine repetitive peptide segments connected to the protein were detected; however, its ratio of 6-10B to 5-8 F only achieved 1.19, indicating a clear exploring value for NUCB-2 in tumorigenesis of NPC. The gene discussed is NUCB2; the disease is nasopharyngeal carcinoma.