The genes co-regulated by Acu-exo and sepsis were derived from multiple organs and systems, their interacting genes(HSP90AA1, GRB2, EGFR etc.)and signaling pathways(MAPK, TNF, JAK-STAT etc.)were involved in inflammation, immune regulation, metabolism, and cell proliferation and apoptosis. The gene discussed is GRB2; the disease is Sepsis.