The reactive oxygen species (ROS) plays a pivotal role in the pathogenesis of diabetes and its complications such as CAD with activation or inactivation of various signaling pathways involved in the exacerbation (as NF-κB-mediated proinflammatory signals) or prevention (as Nrf2 and Sirt1-mediated antioxidant signals) of diabetic disorders, respectively [40]. The gene discussed is NFKB1; the disease is coronary artery disorder.