Figure 4C, D shows the top 20 KEGG signaling pathways: AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, Chagas disease, tumor necrosis factor (TNF) signaling pathway, fluid shear stress and atherosclerosis, lipid and atherosclerosis, C-type lectin receptor signaling pathway, Pertussis, Yersinia infection, T-cell receptor signaling pathway, and IL-17 signaling pathway were key pathways (Fig. 5). This evidence concerns the gene CLEC4D and Yersinia infectious disease.