STAT3 and colorectal carcinoma: In contrast, the conditional medium of TPCLMshTCAF2 suppressed EMT and the Wnt5a/STAT3 signaling axis, leading to attenuated cell migration compared to those regulated by TPCLMshNC medium, while the addition of recombinant Wnt5a reversed the effects of TPCLMshTCAF2 in CRC cells (Figure 4L,N; Figure S23D,E, Supporting Information).