CD248 and neoplasm: TPCs act as a physiological barrier to limit tumor cell intravasation,[47] whereas several TPC subsets, such as CD45−VLA‐1bri, CD248+, and TCF21high TPCs, exert pro‐metastatic effects by promoting tumor cell intravasation.[14, 25, 48] These contradictory effects of TPCs on tumor metastasis may be associated with their heterogeneity.[49] Here, we found that TCAF2 was highly expressed in TPCs from primary tumors, but not in TPCs derived from liver metastatic tumors, which directly facilitated tumor cell EMT, migration, and subsequent intravasation at the initiation of tumor metastasis.