Hypoxia is a common feature of the tumor microenvironment caused by abnormal vascular structure and tumor cell metabolism,[32] which is more pronounced in high‐metastatic tumors than that in low‐metastatic tumors, and the tumor blood vessels and surrounding area are also subject to hypoxia condition in high‐metastatic tumors.[33, 34, 35, 36] Hypoxia has been reported to upregulate TCAF2 level in cancer cells.[21] Therefore, we proposed that the upregulation of TCAF2 in TPCLM might be associated with tumor hypoxia. The gene discussed is TCAF2; the disease is neoplasm.