TRPM8 and colorectal cancer: TRPM8 is the primary cold sensor that can be activated by innocuous cooling (<28 °C) and cooling agents such as menthol and icilin,[18] which is highly expressed in multiple malignant tumors, including prostate, lung, and colorectal cancers, and is involved in tumor proliferation, survival, and invasion.[19] TCAF2 is a partner protein of TRPM8, which binds to the N‐terminal tail of TRPM8[20] and promotes TRPM8 trafficking to the cell surface to gate the ion channel.[55] However, the exact binding site between TCAF2 and TRPM8 is currently unknown.