The role of Wnt5a in cancer progression remains controversial and may be dependent on the cell type.[41, 42] Wnt5a is elevated in metastatic liver, lung, colon, and breast cancer cell lines and its expression is correlated with tumor cell EMT.[37] Consistent with a previous study,[43] we found that Wnt5a secretion from TPCs induced the migration and EMT of CRC cells, thus promoting CRCLM. This evidence concerns the gene WNT5A and breast cancer.