TRPM8 and cancer: TCAF2 is a hypoxia‐related gene with unknown function in lung and breast cancers.[21, 22] TCAF2 binds to TRPM8 to promote its trafficking to the cell surface and to inhibit its ion channel activity, thereby increasing the migration of prostate cancer cells in vitro.[20] However, the role of TCAF2 in TPCs and its regulatory effects on cancer development remain largely unknown.