SRC and Hyperkeratosis: In line with this, several previous studies showed that SRC could play a role in epidermal carcinogenesis: in mouse epidermis, SRC activation induces hyperplasia and hyperkeratosis and promotes tumor, malignant progression and metastasis47, 73, 74 while high SRC expression and activity were evidenced in human actinic keratoses hyperproliferative premalignant skin lesions47.