Inhibition of ATM will promote mitochondrial DNA (mtDNA) leakage and activate the cGAS/STING pathway in murine cancer cells.115 ATM blockade can also increase SRC-dependent type I IFN signalling activation and ICB sensitivity in pancreatic adenocarcinoma.116,117 In another hand, PARP inhibitors are synthetically lethal with BRCA mutations.118 A truncating mutation in BRCA2 other than BRCA1 is associated with a superior response to ICB.119 Another pan-cancer analysis also confirms the association between BRCA2 mutation with pembrolizumab sensitivity.120. The gene discussed is BRCA1; the disease is cancer.