It is worth noting that downregulation of NLRP3 or caspase-1, neutralization of S100A9, and drug inhibition of NLRP3 or NOX inhibit MDS cell pyroptosis, ROS production, and nuclear β-catenin activity, which is sufficient to restore effective hematopoiesis [34]. The gene discussed is NLRP3; the disease is myelodysplastic syndrome.