Through Cox and LASSO analyses, we assessed PRG signals and their possible physiological significance in clinical samples and MM transcriptome data from GEO data and identified 11 characteristics PRG genes related to the prognosis of MM patients: AIM2, CASP1, Elane, GSDMB, GSDMC, IL1B, NLRP1, GZMB, IL1a, CHMP7, and CYCS [50]. This evidence concerns the gene IL1B and Miyoshi myopathy.