GSDMD and acute myeloid leukemia: Evidence has shown that in mouse myeloid cells, small molecular inhibitors of the serine dipeptidase Dpp8/9 can activate the caspase-1 signaling pathway via the inflammasome sensor Nlrp1b, which leads to the cleavage and activation of GSDMD and the formation of a pore in the plasma membrane to mediate cell death and inhibit the progression of acute myeloid leukemia (AML) [19].