Two previous observational studies found that there were rs1800795 (G/C at −174) and rs1800796 (G/A at −597) polymorphisms in IL-6 and that rs1800795 was associated with allergic rhinitis risk.26, 27 Of them, the study from China reported that individuals expressing the C allele of rs1800795 were at higher risk of developing this allergic disease, whereas the other study from Middle Asia concluded that individuals expressing the G allele were more susceptible to allergic rhinitis.26, 27 These contradictory results may be explained by the different study populations. The gene discussed is IL6; the disease is allergic disease.