IFNG and malaria: Among primigravid women, IL-10 producing nnCD4+ T cells (including IL-10 single-producers and IFNγ+IL-10+ double producers) comprised a greater proportion of the malaria-specific response whereas among multigravid women, TNFα-producing nnCD4+ T cells (including TNFα single-producers and TNFα+ IFNγ+ double producers) comprised the greater proportion (p = 0.0001, Fig. 4b, Supplemental Table S6 [Mann Whitney U test]).