For example, ANGPTL3 has been detected in the kidney, and has been found to contribute to the enhanced cellular apoptosis and sorafenib response in renal cell carcinoma by inhibiting the focal adhesion kinase (Bao et al., 2018); while Angptl3−/− protected against glomerulosclerosis in adriamycin-induced nephropathy by attenuating podocyte loss (Dai et al., 2019). This evidence concerns the gene ANGPTL3 and hereditary clear cell renal cell carcinoma.