For example, hepatocyte-specific deletion of IL1R1 attenuates liver injury (Gehrke et al., 2018), while IL1Ra ameliorates inflammasome-dependent alcoholic steatohepatitis, decreases liver fibrosis, and improves liver regeneration in mouse models (Petrasek et al., 2012; Zhou et al., 2020b). This evidence concerns the gene IL1R1 and Hepatic fibrosis.