ANGPTL3 and acute monocytic leukemia: We next determined the effects of ANGPTL3 on NF-κB activation in immune cells by knocking down ANGPTL3 in THP1 cells, a human monocyte cell line from acute monocytic leukemia, and confirmed that the knockdown of ANGPTL3 in THP1 cells also potentiated IL-1β-induced transcription of downstream genes (Figure 2G).