Additionally, incubation with 1B7/CD3 was shown to induce the activation of Jurkat T cells equipped with an NFAT luciferase reporter when co-cultured with REH-TSLPR cells expressed escalating levels of TSLPR, MHH-CALL4 ALL cells, and primary ALL blasts (Fig. 2D–E). This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.