A total of 15 genes (ATP6V1F, BUD31, COPS6, CPSF4, NUP205, MCM7, MEPCE, NRF1, POLR2J, PMPCB, PSMC2, SRRT, TAF6, TNPO3, TRRAP) for which, CRISPR/shRNA KO demonstrated a significantly reduced leukemic cell proliferation and suggested that they are essential for leukemia cell survival and possible synthetic lethal targets for -7/del7q MN (Fig. 7A). The gene discussed is COPS6; the disease is leukemia.