CRTAC1 and non-small cell lung carcinoma: Consistent with the intracellular calcium results, dantrolene treatment decreased the apoptosis rate of CRTAC1-overexpressing NSCLC cells, indicating that overexpression of CRTAC1 in NSCLC cells increases the intracellular calcium concentration induced by cisplatin through the RyR channel, thereby enhancing cisplatin-induced apoptosis.