To further explore the contribution of CRTAC1 expression to cisplatin sensitivity, different siRNAs were employed to knock down CRTAC1 in NSCLC cell lines with lower IC50 values for cisplatin (A549, IC50 = 9.495 μM and H1975, IC50 = 4.519 μM). Here, CRTAC1 is linked to non-small cell lung carcinoma.