In this study, Gene Expression Omnibus (GEO) dataset analysis showed, for the first time, that cisplatin treatment in NSCLC patients with high CRTAC1 expression levels is associated with better overall survival, suggesting that CRTAC1 might play a role in the efficacy of cisplatin chemotherapy in NSCLC. Here, CRTAC1 is linked to non-small cell lung carcinoma.