Consistent results were observed in the lung adenocarcinoma (LUAD) patient cohort (Fig. 1G–I), where the NRF2 pathway and nuclear receptor metapathway, which encompass the majority of NRF2 target genes, were significantly upregulated in KEAP1-mutated samples (Fig. 1G). Here, NFE2L2 is linked to lung adenocarcinoma.