All the tested therapies were effective in preventing renal fibrosis and α-SMA accumulation, while only TAM and the association of LOS + MMF + TAM significantly reduced collagen I and fibronectin accumulation in this CKD model, suggesting that TAM promoted additional antifibrotic effect to the therapeutic scheme, with no impairment of renoprotective action of LOS and MMF, when associated to these drugs. Here, FN1 is linked to renal fibrosis.