According to these quantifications, NAME animals exhibited significant renal fibrosis, evidenced by the positivity for Masson staining (1.7 ± 0.3 vs. 0.3 ± 0.1% in Control), as well as marked α-SMA accumulation (16.2 ± 3.5 vs. 0.4 ± 0.1% in Control), compared to Control rats. The gene discussed is ACTA1; the disease is renal fibrosis.