BRD2 and primary ovarian failure: In addition, the results of another study demonstrated that miR-22-3p was significantly down-regulated in the serum of patients with premature ovarian failure and that it correlated negatively with serum follicle-stimulating hormone (FSH) levels; logistic-regression analysis revealed that miR-22-3p protected against premature ovarian failure; bioinformatics analysis suggested miR-22-3p target genes might be associated with apoptosis, autophagy, and tumourigenesis [24].