Approximately 50-70% of patients with PCOS are insulin resistant: some data showed that miR-193b, miR-194, and miR-122 were significantly up-regulated in patients with PCOS patients and impaired glucose tolerance, and functional analysis of the target genes suggested that these miRNAs might help regulate glycolipid metabolism and follicular development [28]. Here, INS is linked to polycystic ovary syndrome.