Here, we examined copy number, mRNA expression as well as survival curve data from several tumors and revealed that a co-amplification of CBX3 gene with either EGFR or RAC1 gene is a molecular event occurring in a wide spectrum of human cancers and yields a statistically significant increase of both mRNA and protein levels of CBX3, EGFR and RAC1. This evidence concerns the gene RAC1 and cancer.