We found that, similarly to what previously described for CBX3 and EGFR, whereas 90–95% of samples which are diploid for CBX3 are diploid for RAC1 (Fig. 3A–I), the tumors displaying gene amplification in CBX3 locus show a dramatic enrichment in the frequency of both low (gain) and high (amplification) CN increase of RAC1 (Fig. 3A–I), (10–40% and the 10–60% of the tumor specimens, respectively). Here, EGFR is linked to neoplasm.