The TCGA Pan Cancer Atlas specimens showing simultaneous amplification of CBX3 with either EGFR or RAC1 genes revealed no significant changes in either the aneuploidy score or the fraction of genome altered compared to diploid tumor samples (Supplementary Fig. 1B–E), thus, rendering unlikely that gene co-amplification may result from an increased genome instability. This evidence concerns the gene EGFR and neoplasm.