EGFR and neoplasm: We found that, whereas in the 85–95% of the cases EGFR diploidy was associated with the CBX3 diploidy (Fig. 2A–I), the tumors displaying gene amplification of EGFR locus show a dramatic enrichment in the frequency of both low (gain; 10–90% of tumor specimens) and high (amplification; 5–80%) increase of CBX3 CN (Fig. 2A–I).