On the other hand, cancer samples from TCGA Pan Cancer Atlas Studies harboring high CN increase in RAC1 gene display enhanced expression of CBX3 RNAs (Supplementary Fig. 6K), thus further confirming that gene amplification of RAC1 and CBX3 leads to an increase of CBX3 and RAC1 mRNAs, respectively in human cancers. Here, RAC1 is linked to cancer.