In line with the genomic datasets, mass spectrometry data in NSCLC samples from the CPTAC (See Materials and Methods section) bearing either low or high gain of RAC1 CN reveal a significant increase of CBX3 protein levels, and analogously, specimens with multiple copies of CBX3 show a statistically significant enrichment of RAC1 protein (Fig. 4N, O). Here, RAC1 is linked to non-small cell lung carcinoma.