Indeed, cells that overexpress/upregulate CBX3, elicit cancer proliferation properties [3, 5, 6] and their persistence is considered a poor prognosis marker in a plethora of human cancers such as glioblastoma multiforme (GBM) [7], non-small cell lung cancer (NSCLC) [8], ovarian cancer [9], breast cancer (BRCA) [10, 11], osteosarcoma [5], hepatocellular carcinoma [6], gastric cancer [12], pancreatic adenocarcinoma [4] and prostate cancer [13]. Here, CBX3 is linked to non-small cell lung carcinoma.