The first notable finding of our study is to provide convincing evidences supporting a rather definitive role of SPDEF in facilitating the proliferation, migration and invasion of luminal BC cells in vitro (Fig. 2 and Figures S1, S2) as well as promoting luminal BC oncogenesis and progression in vivo (Figs. 1 and 3L-N, Table 1). The gene discussed is SPDEF; the disease is breast cancer.