Although the literature shows a heavy focus on Programmed Death Ligand expression in the context of tumor cells and lymphocytes, we found preferentially PD-L2 expression by myCAFs of the ‘activated’ TME and proposed a potential signaling axis with Regulatory T-Cells via PD1 (PDCD1) (Fig. 3i)82. Here, PDCD1LG2 is linked to neoplasm.