The 184-residue cGGNBP2 microprotein encoded by a circRNA plays a positive regulatory role in modulating the IL-6/STAT3 signaling pathway by directly interacting with and phosphorylating STAT3, and could serve as an auxiliary target for the development of clinical treatments for intrahepatic cholangiocarcinoma by targeting the IL-6/STAT3 pathway [45]. The gene discussed is STAT3; the disease is intrahepatic cholangiocarcinoma.