CCK-8 assays noted that at 3 and 4 days, miR-297 inhibitor induced cell growth while LY294002 or miR-297 mimic treatment led to opposite trend; relative to inhibitor treatment, miR-297 inhibitor + si-PTBP3 or miR-297 inhibitor + LY294002 treatment suppressed cell proliferation of HCC cell lines (Fig. 6J). This evidence concerns the gene PTBP3 and hepatocellular carcinoma.