Additionally, miR-297 inhibitor induced invasiveness, and migration of HCC cells while LY294002 or miR-297 mimic transfection led to opposite trend; relative to miR-297 inhibitor treatment, miR-297 inhibitor + si-PTBP3 or miR-297 inhibitor + LY294002 treatment suppressed invasion, and migration of HCC cells (Fig. 6K, L). This evidence concerns the gene PTBP3 and hepatocellular carcinoma.