For example, a MIR100HG/hnRNPA2B1/TCF7L2 feedback loop may be activated by the miRNA-host gene lncRNA MIR100HG, a powerful inducer of epithelial-to-mesenchymal transition in colorectal cancer, and may help explain cetuximab resistance and metastasis [27]. This evidence concerns the gene HNRNPA2B1 and colorectal cancer.