We then determined the effect of both 2HG enantiomers on CD8+ T cell anti-tumor activity by injecting C57BL/6j mice with B16-F10 OVA-expressing tumor cells and adoptively transferring OT-I CD8+ T cells that had been pre-treated with OE-S-2HG, OE-R-2HG, or vehicle (Figure 5K). Here, CD8A is linked to neoplasm.