The authors used high concentrations of cell-permeable S-2HG in vitro, observed a reduction in CD8+ T cell migration, and concluded that S-2HG suppresses anti-tumor activity.13 In contrast, we reported that exogenous treatment of mouse and human CD8+ T cells with OE-S-2HG favors a memory phenotype and increases anti-tumor activity in multiple adoptive T cell transfer models.11,17. Here, CD8A is linked to neoplasm.