BCAT1 and glioblastoma: R-2HG can inhibit the αKG-dependent transaminases BCAT1/2 (branched chain amino acid transaminases 1/2) more potently than S-2HG, and R-2HG accumulation lowers glutamate production in glioblastoma cells.33 This is in agreement with our observations in CD8+ T cells (Figure 4E) and implies that the reduction of glutamate in OE-R-2HG-treated cells could be in part due to the differential inhibition of αKG-dependent transaminases.