The association between CAFs and survival in patients with advanced high‐grade serous ovarian cancer(HGSC) has attracted the attention of Ferri‐Borgogno et al.[89] Ligand‐receptor analysis at the mesenchymal‐tumor interface showed that APOE (ligand expressed on CAFs)‐LRP5 (receptor expressed on tumor cells) was present in both short‐term survival patient samples, and subsequent cell experiments also demonstrated the effect of this crosstalk network on HGSC cell survival. Here, APOE is linked to neoplasm.