By scRNA‐seq and SRT sequencing of paired samples of CRC and liver metastasis, Wu et al.[9] found that immunosuppressive cells such as SPP1+ macrophages and MRC1+CCL18+ macrophages were specifically enriched in liver metastasis samples and which was validated in open independent cohorts, revealing the role of these macrophage subpopulations in the tumor‐primary ecological niche of CRLM formation. Here, SPP1 is linked to neoplasm.