Further, the authors found that FAP+ fibroblasts and SPP1+ macrophages co‐localized spatially (Figure 2a), and promoted connective tissue proliferation through complex interactions such as reciprocal recruitment and activation to limit the infiltration of immune cells into the tumor interior, leading to further deterioration of CRC microenvironment and ultimately to a reduction in the efficacy of PD‐L1 therapy. Here, SPP1 is linked to colorectal carcinoma.