Cancer regions and PIN regions also have region‐specific markers, for example, genes SPINK1 and PGC are enriched in the former and NPY is highly expressed in the latter.[61] From a clinical point of view, pathologists can refer to the results of this analysis to give special attention to regions of high expression of cancer‐related genes in order to determine the extent of the lesion at an early stage before any histological changes are present. This evidence concerns the gene SPINK1 and cancer.