Factor analysis[61] revealed the involvement of IGLL5 and CD74 in this cluster separation and their specific presence in both regions, suggesting that gene expression program in the lymphoid tissue is influenced by the distance of tumor cells.[71] TGF‐β signaling between tumor cells and TME cells, especially NK, mast, and MALT B cells, plays a key role in the invasion of advanced LUAD.[74] One macrophage subpopulation, Mac.CCL3.4, expressed high M1 and low M2 characteristics, while another, Mac.FABP5, expressed high M1 and M2 characteristics. Here, TGFB1 is linked to neoplasm.