It has been reported that PUF60 is overexpressed in various cancers, including bladder cancer [9], colon cancer [10], hepatocellular carcinoma [11], non-small cell lung cancer [12], breast cancer [13, 14], esophageal cancer [15] and renal cell carcinoma [16], and its overexpression is closely related to its development and progression. The gene discussed is PUF60; the disease is hereditary clear cell renal cell carcinoma.