Recent studies show that PUF60 is highly expressed and promotes tumor growth in various types of tumors, in breast cancer, the expression of PUF60 was elevated and its high expression was closely associated with the high incidence of lymph node metastasis and advanced TNM stage, and its upregulation of PUF60 significantly increased the growth, migration, and invasion and repressed the apoptosis through decreased PTEN expression [13]. The gene discussed is PTEN; the disease is metastatic malignant neoplasm in the lymph nodes.