APOA4 and aortic stenosis: In patients with aortic stenosis, a comparison of ECM samples from TAV (26 patients) and BAV (41 patients) revealed similar differences to those found in the general AVD cohort and all the markers mentioned above had significant differences in the abundances with the exception of Apolipoprotein A-IV that demonstrated a similar trend of enrichment (Fig. 5A, B and Supplementary Table 4).