Inclusion: UACR of 30 to <300 mg/g, eGFR of 25 to <60 mL/min/1.73 m2, and history of diabetic retinopathy; or UACR of 300-5,000 mg/g, eGFR of 25 to <75 mL/min/1.73 m2, serum potassium of ≤4.8 mEq/L, and on a maximum tolerated dose of an ACEi or ARB. Exclusion: Nondiabetic kidney disease, uncontrolled hypertension, HbA1c of >12%, HFrEF (NYHA class II-IV), and already taking eplerenone, spironolactone, a renin inhibitor, or a potassium-sparing diuretic. The gene discussed is REN; the disease is kidney disorder.