Inclusion: UACR of 30 to <300 mg/g and eGFR of 25-90 mL/min/1.73 m2; or UACR of 300-5,000 mg/g, eGFR of ≥60 mL/min/1.73 m2, serum potassium of ≤4.8, and on a maximum tolerated dose of an ACEi or ARB. Exclusion: UACR of 300-5,000 mg/g and eGFR of 25 to <60 mL/min/1.73 m2; or nondiabetic kidney disease; or uncontrolled hypertension; or HbA1c of >12%; or HFrEF (NYHA class II-IV); or already taking eplerenone, spironolactone, a renin inhibitor, or a potassium-sparing diuretic. The gene discussed is REN; the disease is kidney disorder.