We used a CRISPR/Cas9-based knockout strategy to deplete the described candidates in human lung carcinoma epithelial A549 cells expressing the SARS-CoV-2 entry receptor ACE2 and H2B-mRFP (A549-H2B-mRFP-ACE2) (Supplementary Table S1). Here, H2BC21 is linked to lung carcinoma.