However, this inference contradicts the clinics: the pathogenicity of the omicron variant is lower compared to the wild-type strain; this observation could be explained if the binding of the omicron S-protein to the ACE2 receptor is weaker at pH 7.4 (in the blood plasma), taking into consideration that the coronavirus system pathogenicity is a result of damage to the epithelial cells in the blood capillary leading to the formation of microthrombi in the vessels of all visceral organs; the clinics show that the coronavirus disease is most severe in patients with cardiovascular disorders. The gene discussed is PROS1; the disease is cardiovascular disorder.