For instance, circBART2.2, an EBV-encoded circRNA, was reported to be significantly upregulated in nasopharyngeal carcinoma (NPC), where it upregulates programmed death-ligand 1 (PD-L1) expression levels and inhibits T-cell functions in vivo and in vitro [115]. The gene discussed is CD274; the disease is nasopharyngeal carcinoma.