To test whether SARS-CoV-2 Mpro would induce LPCAT3 cleavage in all types of cells, pcDNA3.1-SCV2 Mpro was used to transfect a series of cell lines, including human colorectal cancer-derived HCT116 cells (Figure 2A), human cervical cancer-derived HeLa cells (Figure 2B), human hepatocellular cancer-derived HuH-7 cells (Figure 2C), and human breast cancer-derived MCF-7 cells (Figure 2D). This evidence concerns the gene LPCAT3 and colorectal cancer.