Therefore, the combination of a CAV2-based vector and ISA 201 may prove to be a valuable tool for developing vaccines against major diseases that threaten production animals, such as foot-and-mouth disease (CAV2-ΔE3-VP1 [23] and CAV2-ΔE1-P1/3C [8]), porcine reproductive and respiratory syndrome (CAV2-ΔE3-GP5 [4]), peste des petits ruminants (CAV2-ΔE3-H) [5]), or bluetongue (CAV2-ΔE1-VP7 [3]). This evidence concerns the gene CAV2 and foot and mouth disease.