These exosomal DEPs might play important molecular signaling roles in cellular immunity and viral infection; e.g., ITGB1 is a transmembrane receptor that mediates the connection between the cell and its external environment [42], which was recently found to be a co-receptor for angiotensin-converting enzyme 2 (ACE2), enhancing the binding of novel coronavirus proteins to their receptor ACE2 [43]. The gene discussed is ACE2; the disease is viral infectious disease.